Description
Product Characteristics: TGS1 (Trimethylguanosine Synthase 1) is a Protein Coding gene. Diseases associated with TGS1 include Hepatocellular Carcinoma. Among its related pathways are Transport of the SLBP independent Mature mRNA and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and RNA trimethylguanosine synthase activity.
Target Information: Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation (By similarity)